Pathology EMQ template.

Name:

Candidate number:

Theme: Myeloproliferative Disorders

 

OPTION LIST

 

A

ALL

I

Myelofibrosis

B

AML

J

Primary Polycythaemia

C

CLL

K

Secondary Polycythaemia

D

CML

L

 

E

Chuvasch Polycythaemia

M

 

F

Essential Thrombocythaemia

N

 

G

Gaisböck’s syndrome

O

 

H

Myelodysplasia

P

 

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. A 67 year-old man presents to his GP feeling depressed and suffering from general malaise. He complains of some visual disturbances and gout. He has a history of angina. On examination he appears cyanosed, with a BP of 180/100 and has hepatosplenomegaly.

 

2. An overweight 70 year-old woman presents with shortness of breath and a swollen, painful right leg. She is a heavy smoker. Blood tests reveal Hb 17g/dl, PCV 0.52, WBC 13x109/l

 

3. A 75 year-old man, with a history of polycythaemia vera, presents with bruising and malaise. On examination he has splenomegaly. Blood tests show Hb 9g/dl, WBC 150x109/l. FISH shows no chromosomal abnormalities.

 

4. A 75 year-old man, with a history of polycythaemia vera, presents with bruising and malaise. On examination he has splenomegaly. Blood tests show Hb 8.5g/dl, WBC 200x109/l. FISH shows a chromosomal translocation t(9;22)

 

5. A 70 year-old lady contracts a chest infection while being treated in hospital for a UTI. Blood tests show a pancytopenia. A bone marrow aspirate shows ring sideroblasts.

 

ANSWERS

1. J

2. K

3. I

4. D

5. H